Publications

Colon Cancer

Zou H, Harrington JJ, Shire AM, Rego RL, Wang L, Campbell ME, Oberg AL, Ahlquist DA.

Highly methylated genes in colorectal neoplasia: implications for screening.

Cancer Epidemiol Biomarkers Prev. 2007;16(12):2686-96.

Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB.

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.

PLoS Genet. 2007;3(9):1709-23.

Zitt M, Zitt M, Müller HM.

DNA methylation in colorectal cancer--impact on screening and therapy monitoring modalities?

Dis Markers. 2007;23(1-2):51-71. Review.

Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez NS, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JP.

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

Proc Natl Acad Sci U S A. 2007;104(47):18654-9.

Additional Publications

Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM.
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.
Genes Chromosomes Cancer. 2006;45(8):781-9.

Jubb AM, Bell SM, Quirke P.
Methylation and colorectal cancer.
J Pathol. 2005;195(1):111-134

Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A, Markowitz SD.
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.
J Natl Cancer Inst. 2005;97(15):1124-32.

Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB.
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Mol Cell Biol. 2003;23(23):8429-39.

Schuebel K, Chen W, Baylin SB.
CIMPle origin for promoter hypermethylation in colorectal cancer?
Nat Genet. 2006;38(7):738-40.

Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, Sheahan K.
Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.
J Mol Diagn. 2006;8(1):68-75.

Wynter CV, Kambara T, Walsh MD, Leggett BA, Young J, Jass JR.
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
Int J Cancer. 2006;118(4):907-15

Takahashi T, Shigematsu H, Shivapurkar N, Reddy J, Zheng Y, Feng Z, Suzuki M, Nomura M, Augustus M, Yin J, Meltzer SJ, Gazdar AF.
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
Int J Cancer. 2006; 118:924-31

Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP.
MGMT promoter methylation and field defect in sporadic colorectal cancer.
J Natl Cancer Inst. 2005;97(18):1330-8.

Grady WM.
Epigenetic events in the colorectum and in colon cancer.
Biochem Soc Trans. 2005;33(Pt 4):684-8.

Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM.
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.
Clin Cancer Res. 2005;11(3):1203-9.

Frigola J, Sole X, Paz MF, Moreno V, Esteller M, Capella G, Peinado MA.
Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer.
Hum Mol Genet. 2005;14(2):319-26.

Bai AH, Tong JH, To KF, Chan MW, Man EP, Lo KW, Lee JF, Sung JJ, Leung WK.
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Int J Cancer. 2004;112(5):846-53.

Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS.
Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.
Clin Cancer Res. 2004;10(22):7475-83.

Nagasaka T, Sasamoto H, Notohara K, Cullings HM, Takeda M, Kimura K, Kambara T, MacPhee DG, Young J, Leggett BA, Jass JR, Tanaka N, Matsubara N.
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
J Clin Oncol. 2004;22(22):4584-94.

Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ.
BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status.
Am J Surg Pathol. 2004;28(11):1452-9.

Arnold CN, Goel A, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR.
APC Promoter Hypermethylation Contributes to the Loss of APC Expression in Colorectal Cancers with Allelic Loss on 5q.
Cancer Biol Ther. 2004;3(10):960-964

Van Rijnsoever M., Elsaleh H, Joseph D, McCaul K, Iacopetta B.
CpG Island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.
Clin. Can. Res. 2003;9:2898-903.

Van Rijnsoever M., Grieu F, Elsaleh H, Joseph D, Iacopetta B.
Characterization of colorectal cancers showing hypermethylation at multiple CpG islands.
Gut 2002;51:797-802.

Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg M., Herman JG, Baylin S.B.
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.
Nature Genetics 2002;31(2):141-9

Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JP, Sidransky D, Baylin SB, Herman JG.
Inactivation of the DNA repair gene 06-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer Res. 2000;60(9):2368-71.

Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer SJ, Baylin SB, Herman JG.
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Cancer Res. 2000;60(16):4366-71.

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer S.J.
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.
Cancer Res. 2000;60(17):4864-8.

">Colon Cancer

Zou H, Harrington JJ, Shire AM, Rego RL, Wang L, Campbell ME, Oberg AL, Ahlquist DA.

Highly methylated genes in colorectal neoplasia: implications for screening.

Cancer Epidemiol Biomarkers Prev. 2007;16(12):2686-96.

Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB.

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.

PLoS Genet. 2007;3(9):1709-23.

Zitt M, Zitt M, Müller HM.

DNA methylation in colorectal cancer--impact on screening and therapy monitoring modalities?

Dis Markers. 2007;23(1-2):51-71. Review.

Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez NS, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JP.

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

Proc Natl Acad Sci U S A. 2007;104(47):18654-9.

Additional Publications

Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM.
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.
Genes Chromosomes Cancer. 2006;45(8):781-9.

Jubb AM, Bell SM, Quirke P.
Methylation and colorectal cancer.
J Pathol. 2005;195(1):111-134

Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A, Markowitz SD.
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.
J Natl Cancer Inst. 2005;97(15):1124-32.

Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB.
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Mol Cell Biol. 2003;23(23):8429-39.

Schuebel K, Chen W, Baylin SB.
CIMPle origin for promoter hypermethylation in colorectal cancer?
Nat Genet. 2006;38(7):738-40.

Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, Sheahan K.
Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.
J Mol Diagn. 2006;8(1):68-75.

Wynter CV, Kambara T, Walsh MD, Leggett BA, Young J, Jass JR.
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
Int J Cancer. 2006;118(4):907-15

Takahashi T, Shigematsu H, Shivapurkar N, Reddy J, Zheng Y, Feng Z, Suzuki M, Nomura M, Augustus M, Yin J, Meltzer SJ, Gazdar AF.
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
Int J Cancer. 2006; 118:924-31

Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP.
MGMT promoter methylation and field defect in sporadic colorectal cancer.
J Natl Cancer Inst. 2005;97(18):1330-8.

Grady WM.
Epigenetic events in the colorectum and in colon cancer.
Biochem Soc Trans. 2005;33(Pt 4):684-8.

Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM.
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.
Clin Cancer Res. 2005;11(3):1203-9.

Frigola J, Sole X, Paz MF, Moreno V, Esteller M, Capella G, Peinado MA.
Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer.
Hum Mol Genet. 2005;14(2):319-26.

Bai AH, Tong JH, To KF, Chan MW, Man EP, Lo KW, Lee JF, Sung JJ, Leung WK.
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Int J Cancer. 2004;112(5):846-53.

Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS.
Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.
Clin Cancer Res. 2004;10(22):7475-83.

Nagasaka T, Sasamoto H, Notohara K, Cullings HM, Takeda M, Kimura K, Kambara T, MacPhee DG, Young J, Leggett BA, Jass JR, Tanaka N, Matsubara N.
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
J Clin Oncol. 2004;22(22):4584-94.

Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ.
BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status.
Am J Surg Pathol. 2004;28(11):1452-9.

Arnold CN, Goel A, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR.
APC Promoter Hypermethylation Contributes to the Loss of APC Expression in Colorectal Cancers with Allelic Loss on 5q.
Cancer Biol Ther. 2004;3(10):960-964

Van Rijnsoever M., Elsaleh H, Joseph D, McCaul K, Iacopetta B.
CpG Island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.
Clin. Can. Res. 2003;9:2898-903.

Van Rijnsoever M., Grieu F, Elsaleh H, Joseph D, Iacopetta B.
Characterization of colorectal cancers showing hypermethylation at multiple CpG islands.
Gut 2002;51:797-802.

Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg M., Herman JG, Baylin S.B.
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.
Nature Genetics 2002;31(2):141-9

Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JP, Sidransky D, Baylin SB, Herman JG.
Inactivation of the DNA repair gene 06-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer Res. 2000;60(9):2368-71.

Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer SJ, Baylin SB, Herman JG.
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Cancer Res. 2000;60(16):4366-71.

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer S.J.
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.
Cancer Res. 2000;60(17):4864-8.